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                      Influence of narrowband UVB irradiation

                      Type:Uv phototherapy   Time:2014-11-17 15:00:51
                      Influence of narrowband UVB irradiation of serum on autologous serum skin test results.
                      Kaçar N1, Taşli L, Sanlı B, Topsakal M.
                      Author information
                      Erratum in
                      Int J Dermatol. 2013 Oct;52(10):1293. Kaar, Nida [corrected to Kaçar, Nida].
                      Autologous serum skin test (ASST) is an in vivo test to demonstrate circulating endogenous proinflammatory or wheal-inducing 

                      factors in urticaria patients. While ASST was negative in a patient with solar urticaria and in a patient with localized heat 

                      urticaria, test results turned to positive when performed with visible light-irradiated and heated serums, respectively. 

                      These data suggest that some factors and/or antibodies in serum may be activated or inhibited with different factors. We 

                      aimed to investigate whether or not ASST results change when performed with narrowband ultraviolet B (UVB)-irradiated serum.
                      MATERIALS AND METHODS:
                      Seventy-seven patients with chronic idiopathic urticaria underwent ASST twice in consecutive days. The second ASST was 

                      performed with narrowband UVB-irradiated serum. The results of the first and second ASSTs were compared.
                      The first ASST results were positive in 46 (59.7%) patients. ASST results reversed oppositely in 36 (46.8%) patients, turned 

                      from negative to positive in 19 patients, and turned from positive to negative in 17 patients when performed with narrowband 

                      UVB-irradiated serum.
                       Our results suggest that narrowband UVB may have modifying effects on some wheal-inducing factors and/or antibodies. On which 

                      factors in serum narrowband UVB has effects may be investigated.
                      © 2013 The International Society of Dermatology.

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