<menuitem id="hln37"><dfn id="hln37"></dfn></menuitem>

    <listing id="hln37"><big id="hln37"><progress id="hln37"></progress></big></listing>

                <address id="hln37"><progress id="hln37"><progress id="hln37"></progress></progress></address>

                  <address id="hln37"></address>
                  <form id="hln37"></form>

                      <dfn id="hln37"><th id="hln37"></th></dfn><thead id="hln37"></thead>
                      <big id="hln37"></big>
                      <address id="hln37"><listing id="hln37"><address id="hln37"></address></listing></address>

                      Oxidation Reduction is a Key Process for Successful Treatment of Psoriasis by Narrow-band UVB Phototherapy.

                      Type:Uv phototherapy   Time:2014-11-18 16:01:03

                      Oxidation Reduction is a Key Process for Successful Treatment of Psoriasis by Narrow-band UVB Phototherapy.
                      Gu X1, Nylander E, Coates PJ, Nylander K.
                      Author information
                      Abstract
                      Narrow-band UVB (NB-UVB) phototherapy is commonly used for treatment of psoriasis, though the mechanisms underlying its 

                      efficacy have not been completely elucidated. We used gene expression profiling to characterise gene expression in lesional 

                      epidermis from psoriasis patients in the middle and late stages of NB-UVB photo-therapy. Increased melanogenesis gene 

                      expression was the earliest response to phototherapy. At the end of treatment, genes responding to phototherapy and 

                      correlated to treatment outcome were involved in oxidation reduction, growth and mitochondria organisation. Particularly, 

                      SPATA18, a key regulator of mitochondrial quality, was significantly down-regulated in psoriasis (p < 0.05). Poly(dA:dT) and 

                      poly(I:C) stimulation increased SPATA18 level in primary keratinocytes, indicating the importance of mitochondria quality 

                      control under innate immune induced oxidative stress. Normalised SPATA18 expression after phototherapy indicates improved 

                      mitochondrial quality control and restored cellular redox status. Our data suggest that oxidation reduction is critical for 

                      the resolution of psoriatic plaques following NB-UVB phototherapy.
                      www.superogira.com----The leader manufacturer of UV Phototherapy.
                      久久久综合九色综合中文网_男人的天堂免费视频一色屋_20岁chinese青年男同志_成本人视频动漫免费无码